RhoA/ROCK-2 Pathway Inhibition and Tight Junction Protein Upregulation by Catalpol Suppresses Lipopolysaccaride-Induced Disruption of Blood-Brain Barrier Permeability

RhoA/ROCK-2 Pathway Inhibition and Tight Junction Protein Upregulation by Catalpol Suppresses Lipopolysaccaride-Induced Disruption of Blood-Brain Barrier Permeability

Lipopolysaccaride (LPS) directly or indirectly injures brain microvascular endothelial cells (BMECs) and damages the intercellular tight junction that gives rise to altered blood-brain barrier (BBB) permeability. Catalpol plays a protective role in LPS-induced injury, but whether catalpol protects a...

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Bibliographic Details
Main Authors: Shan Feng, Li Zou, Hongjin Wang, Ran He, Ke Liu, Huifeng Zhu
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
catalpol
LPS
BBB
tight junction
RhoA/ROCK2
Online Access:http://www.mdpi.com/1420-3049/23/9/2371

Internet

http://www.mdpi.com/1420-3049/23/9/2371

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