N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca2+ Mobilization

N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca2+ Mobilization

Resistance of cancer cells to chemotherapy remains a significant problem in oncology. Mechanisms regulating programmed cell death, including apoptosis, autophagy or necrosis, in the treatment of cancers have been extensively investigated over the last few decades. Autophagy is now emerging as an imp...

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Bibliographic Details
Main Authors: Betty Y. K. Law, Simon W. F. Mok, Juan Chen, Francesco Michelangeli, Zhi-Hong Jiang, Yu Han, Yuan Q. Qu, Alena C. L. Qiu, Su-Wei Xu, Wei-Wei Xue, Xiao-Jun Yao, Jia Y. Gao, Masood-ul-Hassan Javed, Paolo Coghi, Liang Liu, Vincent K. W. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
N-desmethyldauricine
SERCA
autophagy
autophagic cell death
apoptosis-resistant
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00388/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00388/full

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