Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

Skeletal muscle mitochondrial dysfunction is believed to play a role in the progression and severity of amyotrophic lateral sclerosis (ALS). The regulation of transcriptional co-activators involved in mitochondrial biogenesis and function in ALS is not well known. When compared with healthy control...

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Bibliographic Details
Main Authors: Aaron P. Russell, Shogo Wada, Lodovica Vergani, M. Benjamin Hock, Séverine Lamon, Bertrand Léger, Takashi Ushida, Romain Cartoni, Glenn D. Wadley, Peter Hespel, Anastasia Kralli, Gianni Soraru, Corrado Angelini, Takayuki Akimoto
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
Peroxiome proliferator activator receptor γ co-activator‐1
Mitofusin
Skeletal muscle
MicroRNA
ALS (amyotrophic lateral sclerosis)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003026

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http://www.sciencedirect.com/science/article/pii/S0969996112003026

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