Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers.

Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers.

<h4>Background</h4>Hypertension (HTN) disproportionately affects African Americans (AAs), who respond better to thiazide diuretics than other antihypertensives. Variants of the APOL1 gene found in AAs are associated with a higher rate of kidney disease and play a complex role in cardiova...

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Bibliographic Details
Main Authors: Patrick N Cunningham, Zhiying Wang, Megan L Grove, Rhonda M Cooper-DeHoff, Amber L Beitelshees, Yan Gong, John G Gums, Julie A Johnson, Stephen T Turner, Eric Boerwinkle, Arlene B Chapman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221957

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https://doi.org/10.1371/journal.pone.0221957

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