Qingda granule attenuates cardiac fibrosis via suppression of the TGF-β1/Smad2/3 signaling pathway in vitro and in vivo

Qingda granule attenuates cardiac fibrosis via suppression of the TGF-β1/Smad2/3 signaling pathway in vitro and in vivo

Cardiac fibrosis plays an important role in hypertension-related contractile dysfunction and heart failure. Qingda granule (QDG), derived from the Qingxuan Jiangya decoction, has been used clinically for more than 60 years to treat hypertension. However, the effect of QDG on hypertensive cardiac fib...

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Bibliographic Details
Main Authors: Xiaoping Chen, Linzi Long, Ying Cheng, Jianfeng Chu, Zhiqing Shen, Liya Liu, Jiapeng Li, Qiurong Xie, Huixin Liu, Meizhu Wu, Youqin Chen, Jun Peng, Aling Shen
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Qingda granule
Hypertension
Cardiac fibrosis
TGF-β1/Smad2/3
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221001037

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http://www.sciencedirect.com/science/article/pii/S0753332221001037

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