Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors

Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors

Dendritic cells (DCs) initiate adaptive immune responses after their migration to secondary lymphoid organs. The LXR ligands/oxysterols and the RXR ligand 9-cis Retinoic Acid (9-cis RA) were shown to dampen DC migration to lymphoid organs through the inhibition of CCR7 expression. We performed trans...

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Bibliographic Details
Main Authors: Raffaella Fontana, Laura Raccosta, Lucrezia Rovati, Knut R. Steffensen, Aida Paniccia, Tomas Jakobsson, Giulio Melloni, Alessandro Bandiera, Giorgia Mangili, Alice Bergamini, Daniela Maggioni, Claudio Doglioni, Roberto Crocchiolo, Marina Cella, Michela Mattioli, Cristina Battaglia, Marco Colonna, Vincenzo Russo
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:OncoImmunology
Subjects:
lxr nuclear receptors
rar/rxr nuclear receptors
dendritic cells
trem-1
lung cancer
ovarian cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1554967

Internet

http://dx.doi.org/10.1080/2162402X.2018.1554967

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