Ad35 and ad26 vaccine vectors induce potent and cross-reactive antibody and T-cell responses to multiple filovirus species.

Ad35 and ad26 vaccine vectors induce potent and cross-reactive antibody and T-cell responses to multiple filovirus species.

Filoviruses cause sporadic but highly lethal outbreaks of hemorrhagic fever in Africa in the human population. Currently, no drug or vaccine is available for treatment or prevention. A previous study with a vaccine candidate based on the low seroprevalent adenoviruses 26 and 35 (Ad26 and Ad35) was s...

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Bibliographic Details
Main Authors: Roland Zahn, Gert Gillisen, Anna Roos, Marina Koning, Esmeralda van der Helm, Dirk Spek, Mo Weijtens, Maria Grazia Pau, Katarina Radošević, Gerrit Jan Weverling, Jerome Custers, Jort Vellinga, Hanneke Schuitemaker, Jaap Goudsmit, Ariane Rodríguez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3516506?pdf=render

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http://europepmc.org/articles/PMC3516506?pdf=render

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