The Subcellular Distribution of Ryanodine Receptors and L-Type Ca2+ Channels Modulates Ca2+-Transient Properties and Spontaneous Ca2+-Release Events in Atrial Cardiomyocytes

The Subcellular Distribution of Ryanodine Receptors and L-Type Ca2+ Channels Modulates Ca2+-Transient Properties and Spontaneous Ca2+-Release Events in Atrial Cardiomyocytes

Spontaneous Ca2+-release events (SCaEs) from the sarcoplasmic reticulum play crucial roles in the initiation of cardiac arrhythmias by promoting triggered activity. However, the subcellular determinants of these SCaEs remain incompletely understood. Structural differences between atrial and ventricu...

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Bibliographic Details
Main Authors: Henry Sutanto, Bart van Sloun, Patrick Schönleitner, Marc A. M. J. van Zandvoort, Gudrun Antoons, Jordi Heijman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
calcium
sarcoplasmic reticulum
ryanodine receptor
spontaneous calcium releases
atrial fibrillation
subcellular distribution
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01108/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01108/full

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