Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression

Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression

E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis. We now demonstra...

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Bibliographic Details
Main Authors: Robert A. H. van de Ven, Milou Tenhagen, Wouter Meuleman, Jeske J. G. van Riel, Ron C. J. Schackmann, Patrick W. B. Derksen
Format: Article
Language:English
Published: The Company of Biologists 2015-04-01
Series:Disease Models & Mechanisms
Subjects:
p120-catenin
Kaiso
Breast cancer metastasis
Anoikis resistance
Online Access:http://dmm.biologists.org/content/8/4/373

Internet

http://dmm.biologists.org/content/8/4/373

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