Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression
E-cadherin inactivation underpins the progression of invasive lobular breast carcinoma (ILC). In ILC, p120-catenin (p120) translocates to the cytosol where it controls anchorage independence through the Rho-Rock signaling pathway, a key mechanism driving tumor growth and metastasis. We now demonstra...
Main Authors: | Robert A. H. van de Ven, Milou Tenhagen, Wouter Meuleman, Jeske J. G. van Riel, Ron C. J. Schackmann, Patrick W. B. Derksen |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2015-04-01
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Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/8/4/373 |
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