Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale

Genes expressing circadian RNA rhythms are enriched for metabolic pathways, but the adaptive significance of cyclic gene expression remains unclear. We estimated the genome-wide synthetic and degradative cost of transcription and translation in three organisms and found that the cost of cycling gene...

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Bibliographic Details
Main Authors: Guang-Zhong Wang, Stephanie L. Hickey, Lei Shi, Hung-Chung Huang, Prachi Nakashe, Nobuya Koike, Benjamin P. Tu, Joseph S. Takahashi, Genevieve Konopka
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715012139