MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis

MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis

ObjectivesMounting evidence has demonstrated that microRNAs (miRNAs) participate in rheumatoid arthritis (RA). The role of highly conserved miR-15/107 family in RA has not been clarified yet, and hence investigated in this study.MethodsReverse transcription-quantitative polymerase chain reaction (RT...

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Bibliographic Details
Main Authors: Si Wang, Jing Xu, Yuanxu Guo, Yongsong Cai, Xiaoyu Ren, Wenhua Zhu, Manman Geng, Liesu Meng, Congshan Jiang, Shemin Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
DICER1 gene
apoptosis
proliferation
inflammation
miRNA family
miRNA – microRNA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.619392/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.619392/full

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