Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry

Abstract All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues currently is performed by gas or liquid chromatography-mass spectrometry (GC- or LC-MS) or biochemical detection. While these methods a...

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Bibliographic Details
Main Authors: Rémi Longuespée, Annika K. Wefers, Elena De Vita, Aubry K. Miller, David E. Reuss, Wolfgang Wick, Christel Herold-Mende, Mark Kriegsmann, Peter Schirmacher, Andreas von Deimling, Stefan Pusch
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Acta Neuropathologica Communications
Subjects:
IDH mutation
2-hydroxyglutarate
Diffuse glioma
MALDI-TOF
Mass spectrometry
Online Access:http://link.springer.com/article/10.1186/s40478-018-0523-3

Internet

http://link.springer.com/article/10.1186/s40478-018-0523-3

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