Computational reconstruction of iron- and manganese-responsive transcriptional networks in alpha-proteobacteria.

We used comparative genomics to investigate the distribution of conserved DNA-binding motifs in the regulatory regions of genes involved in iron and manganese homeostasis in alpha-proteobacteria. Combined with other computational approaches, this allowed us to reconstruct the metal regulatory networ...

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Bibliographic Details
Main Authors: Dmitry A Rodionov, Mikhail S Gelfand, Jonathan D Todd, Andrew R J Curson, Andrew W B Johnston
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.0020163