Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis

Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis

Aims: The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). Methods: TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) mice by a unilateral anterior crossbite (U...

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Bibliographic Details
Main Authors: Aobo Zhang, Shixing Ma, Lingyu Yuan, Shichao Wu, Shaopeng Liu, Xiang Wei, Lei Chen, Chuan Ma, Huaqiang Zhao
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2020-10-01
Series:Bone & Joint Research
Subjects:
temporomandibular joint
osteoarthritis
mir-21-5p
growth differentiation factor 5
interleukin-6
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.910.BJR-2020-0140.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.910.BJR-2020-0140.R1

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