Sigma Receptors as Endoplasmic Reticulum Stress “Gatekeepers” and their Modulators as Emerging New Weapons in the Fight Against Cancer

Sigma Receptors as Endoplasmic Reticulum Stress “Gatekeepers” and their Modulators as Emerging New Weapons in the Fight Against Cancer

Despite the interest aroused by sigma receptors (SRs) in the area of oncology, their role in tumor biology remains enigmatic. The predominant subcellular localization and main site of activity of SRs are the endoplasmic reticulum (ER). Current literature data, including recent findings on the sigma...

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Bibliographic Details
Main Authors: Anna Tesei, Michela Cortesi, Alice Zamagni, Chiara Arienti, Sara Pignatta, Michele Zanoni, Mayra Paolillo, Daniela Curti, Marta Rui, Daniela Rossi, Simona Collina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
sigma receptors
anticancer targeted therapies
chaperone activity
endoplasmic reticulum stress
cancer cell proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00711/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00711/full

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