Specificity, Safety, Efficacy of EGFRvIII-Retargeted Oncolytic HSV for Xenotransplanted Human Glioblastoma

Specificity, Safety, Efficacy of EGFRvIII-Retargeted Oncolytic HSV for Xenotransplanted Human Glioblastoma

Glioblastoma is a lethal primary brain tumor lacking effective therapy. The secluded onset site, combined with the infiltrative properties of this tumor, require novel targeted therapies. In this scenario, the use of oncolytic viruses retargeted to glioblastoma cells and able to spread across the tu...

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Bibliographic Details
Main Authors: Irene Appolloni, Francesco Alessandrini, Laura Menotti, Elisa Avitabile, Daniela Marubbi, Noemi Piga, Davide Ceresa, Francesca Piaggio, Gabriella Campadelli-Fiume, Paolo Malatesta
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
oncolytic virotherapy
glioblastoma stem cells
glioblastoma initiating cells
EGFRvIII
oncolytic HSV
Online Access:https://www.mdpi.com/1999-4915/13/9/1677

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