The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

We have investigated the importance of interleukin-6 (IL-6) in promoting tumor growth and metastasis. In human primary breast cancers, increased levels of IL-6 were found at the tumor leading edge and positively correlated with advanced stage, suggesting a mechanistic link between tumor cell produc...

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Bibliographic Details
Main Authors: Qing Chang, Eirini Bournazou, Pasquale Sansone, Marjan Berishaj, Sizhi Paul Gao, Laura Daly, Jared Wels, Till Theilen, Selena Granitto, Xinmin Zhang, Jesse Cotari, Mary L. Alpaugh, Elisa de Stanchina, Katia Manova, Ming Li, Massimiliano Bonafe, Claudio Ceccarelli, Mario Taffurelli, Donatella Santini, Gregoire Altan-Bonnet, Rosandra Kaplan, Larry Norton, Norihiro Nishimoto, Dennis Huszar, David Lyden, Jacqueline Bromberg
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800784

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http://www.sciencedirect.com/science/article/pii/S1476558613800784

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