Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis

Abstract Corticogenesis is one of the most critical and complicated processes during embryonic brain development. Any slight impairment in corticogenesis could cause neurodevelopmental disorders such as Fragile X syndrome (FXS), of which symptoms contain intellectual disability (ID) and autism spect...

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Bibliographic Details
Main Authors: Cristine R. Casingal, Takako Kikkawa, Hitoshi Inada, Yukio Sasaki, Noriko Osumi
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Molecular Brain
Subjects:
FXS
Online Access:https://doi.org/10.1186/s13041-020-00706-1