Addressing the batch effect issue for LC/MS metabolomics data in data preprocessing

Abstract With the growth of metabolomics research, more and more studies are conducted on large numbers of samples. Due to technical limitations of the Liquid Chromatography–Mass Spectrometry (LC/MS) platform, samples often need to be processed in multiple batches. Across different batches, we often...

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Bibliographic Details
Main Authors: Qin Liu, Douglas Walker, Karan Uppal, Zihe Liu, Chunyu Ma, ViLinh Tran, Shuzhao Li, Dean P. Jones, Tianwei Yu
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-70850-0