Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling

Spironolactone treatment attenuates vascular dysfunction in type 2 diabetic mice by decreasing oxidative stress and restoring NO/GC signaling

Type 2 diabetes (DM2) increases the risk of cardiovascular disease. Aldosterone, which has pro-oxidative and pro-inflammatory effects in the cardiovascular system, is positively regulated in DM2. We assessed whether blockade of mineralocorticoid receptors (MR) with spironolactone decreases ROS-assoc...

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Bibliographic Details
Main Authors: Marcondes Alves Barbosa Da Silva, Thiago eBruder-Nascimento, Stêfany Bruno De Assis Cau, Rheure AM Lopes, Fabiola LAC Mestriner, Rafael S Fais, Rhian M Touyz, Rita C Tostes
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Physiology
Subjects:
Aldosterone
Diabetes Mellitus, Type 2
Oxidative Stress
Vascular Resistance
mineralocorticoid receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00269/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00269/full

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