Circulating mature granzyme B+ T cells distinguish Crohn’s disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn’s disease

Circulating mature granzyme B+ T cells distinguish Crohn’s disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn’s disease

Abstract Background Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that distinguish axSpA, CD, and those with features of both diseases (CD-axSpA) are unknown. This study aimed to address this...

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Bibliographic Details
Main Authors: Adam R. Lefferts, Emilie H. Regner, Andrew Stahly, Becky O’Rourke, Mark E. Gerich, Blair P. Fennimore, Frank I. Scott, Alison E. Freeman, Ken Jones, Kristine A. Kuhn
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Arthritis Research & Therapy
Subjects:
Crohn’s disease
Inflammatory bowel disease
Axial spondyloarthritis
Ankylosing spondylitis
Interferonopathy
Cytotoxic T cells
Online Access:https://doi.org/10.1186/s13075-021-02531-w

Internet

https://doi.org/10.1186/s13075-021-02531-w

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