Discovery and replication of gene influences on brain structure using LASSO regression

Discovery and replication of gene influences on brain structure using LASSO regression

We implemented LASSO (least absolute shrinkage and selection operator) regression to evaluate gene effects in genome-wide association studies (GWAS) of brain images, using an MRI-derived temporal lobe volume measure from 729 subjects scanned as part of the Alzheimer’s Disease Neuroimaging Initiative...

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Bibliographic Details
Main Authors: Omid eKohannim, Derrek P Hibar, Jason L Stein, Neda eJahanshad, Xue eHua, Priya eRajagopalan, Art eToga, Clifford R Jack Jr, Michael W Weiner, Greig I de Zubicaray, Katie L McMahon, Narelle K Hansell, Nicholas G Martin, Margaret J Wright, Paul M Thompson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Neuroscience
Subjects:
Neuroimaging
GWAS
MRI
imaging genetics
LASSO
MACROD2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00115/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00115/full

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