Novel 5-aminosalicylic derivatives as anti-inflammatories and myeloperoxidase inhibitors evaluated in silico, in vitro and ex vivo

Novel 5-aminosalicylic derivatives as anti-inflammatories and myeloperoxidase inhibitors evaluated in silico, in vitro and ex vivo

During the inflammation process, myeloperoxidase (MPO) contributes to the production of reactive species mainly for the destruction of pathogens. When inflammation is dysregulated, the overproduction of reactive species generates cellular damage via the oxidation of biomolecules (proteins, lipids an...

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Bibliographic Details
Main Authors: Laura Cristina Cabrera Pérez, Mara Gutiérrez Sánchez, Jessica Elena Mendieta Wejebe, Maricarmen Hernández Rgodríguez, Manuel Jonathan Fragoso Vázquez, Juan Rodrigo Salazar, José Correa Basurto, Itzia Irene Padilla Martínez, Martha Cecilia Rosales Hernández
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535217300035

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http://www.sciencedirect.com/science/article/pii/S1878535217300035

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