Inhibiting poly(ADP-ribosylation) improves axon regeneration

Inhibiting poly(ADP-ribosylation) improves axon regeneration

The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose) polymerases (PARPs). PARGs, which remove poly(ADP-ribo...

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Bibliographic Details
Main Authors: Alexandra B Byrne, Rebecca D McWhirter, Yuichi Sekine, Stephen M Strittmatter, David M Miller III, Marc Hammarlund
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
axon regeneration
poly(ADP-ribose) polymerase
poly(ADP-ribose) glycohydrolase
dlk-1/MAPKKK
Online Access:https://elifesciences.org/articles/12734

Internet

https://elifesciences.org/articles/12734

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