ATM suppresses SATB1-induced malignant progression in breast epithelial cells.

ATM suppresses SATB1-induced malignant progression in breast epithelial cells.

SATB1 drives metastasis when expressed in breast tumor cells by radically reprogramming gene expression. Here, we show that SATB1 also has an oncogenic activity to transform certain non-malignant breast epithelial cell lines. We studied the non-malignant MCF10A cell line, which is used widely in the...

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Bibliographic Details
Main Authors: Ellen Ordinario, Hye-Jung Han, Saori Furuta, Laura M Heiser, Lakshmi R Jakkula, Francis Rodier, Paul T Spellman, Judith Campisi, Joe W Gray, Mina J Bissell, Yoshinori Kohwi, Terumi Kohwi-Shigematsu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3519734?pdf=render

Internet

http://europepmc.org/articles/PMC3519734?pdf=render

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