Evolutionary analyses of entire genomes do not support the association of mtDNA mutations with Ras/MAPK pathway syndromes.

Evolutionary analyses of entire genomes do not support the association of mtDNA mutations with Ras/MAPK pathway syndromes.

BACKGROUND: There are several known autosomal genes responsible for Ras/MAPK pathway syndromes, including Noonan syndrome (NS) and related disorders (such as LEOPARD, neurofibromatosis type 1), although mutations of these genes do not explain all cases. Due to the important role played by the mitoch...

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Bibliographic Details
Main Authors: Alberto Gómez-Carballa, María Cerezo, Emilia Balboa, Claudia Heredia, Lidia Castro-Feijóo, Itxaso Rica, Jesús Barreiro, Jesús Eirís, Paloma Cabanas, Isabel Martínez-Soto, Joaquín Fernández-Toral, Manuel Castro-Gago, Manuel Pombo, Ángel Carracedo, Francisco Barros, Antonio Salas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3079712?pdf=render

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http://europepmc.org/articles/PMC3079712?pdf=render

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