Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation

Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8+ T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation

The salivary gland is an important tissue for persistence and transmission of multiple viruses. Previous work showed that salivary gland tissue-resident CD8+ T cells elicited by viruses were poorly functional ex vivo. Using a model of persistent murine cytomegalovirus (MCMV) infection, we now show t...

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Bibliographic Details
Main Authors: Corinne J. Smith, Christopher M. Snyder
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
CD8 T cells
tissue-resident CD8+ T cell
PD-1
CD73
cytomegalovirus (CMV)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.704862/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.704862/full

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