Inhibition of cholesterol absorption associated with a PPARα-dependent increase in ABC binding cassette transporter A1 in mice

Inhibition of cholesterol absorption associated with a PPARα-dependent increase in ABC binding cassette transporter A1 in mice

Dietary supplementation with the peroxisome proliferator-activated receptor α (PPARα) ligand WY 14,643 gave rise to a 4- to 5-fold increase in the expression of mRNA for the ATP binding cassette transporter A1 (ABCA1) in the intestine of normal mice. There was no effect in the intestine of PPARα-nul...

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Bibliographic Details
Main Authors: Brian L. Knight, Dilip D. Patel, Sandy M. Humphreys, David Wiggins, Geoffrey F. Gibbons
Format: Article
Language:English
Published: Elsevier 2003-11-01
Series:Journal of Lipid Research
Subjects:
intestine
sterol-regulatory element binding protein
liver X receptor
peroxisome proliferator-activated receptor-α null mice
ω-3 unsaturated fatty acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520336786

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http://www.sciencedirect.com/science/article/pii/S0022227520336786

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