Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.
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2020-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15833-5 |
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doaj-b80c90e12332437a928a3eef0743440d2021-05-11T08:54:23ZengNature Publishing GroupNature Communications2041-17232020-04-0111111810.1038/s41467-020-15833-5Novel metabolic role for BDNF in pancreatic β-cell insulin secretionGianluca Fulgenzi0Zhenyi Hong1Francesco Tomassoni-Ardori2Luiz F. Barella3Jodi Becker4Colleen Barrick5Deborah Swing6Sudhirkumar Yanpallewar7Brad St Croix8Jürgen Wess9Oksana Gavrilova10Lino Tessarollo11Mouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIHMouse Metabolism Core Laboratory, NIDDK, NIHMouse Cancer Genetics Program, CCR, NCI, NIHGlucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.https://doi.org/10.1038/s41467-020-15833-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gianluca Fulgenzi Zhenyi Hong Francesco Tomassoni-Ardori Luiz F. Barella Jodi Becker Colleen Barrick Deborah Swing Sudhirkumar Yanpallewar Brad St Croix Jürgen Wess Oksana Gavrilova Lino Tessarollo |
spellingShingle |
Gianluca Fulgenzi Zhenyi Hong Francesco Tomassoni-Ardori Luiz F. Barella Jodi Becker Colleen Barrick Deborah Swing Sudhirkumar Yanpallewar Brad St Croix Jürgen Wess Oksana Gavrilova Lino Tessarollo Novel metabolic role for BDNF in pancreatic β-cell insulin secretion Nature Communications |
author_facet |
Gianluca Fulgenzi Zhenyi Hong Francesco Tomassoni-Ardori Luiz F. Barella Jodi Becker Colleen Barrick Deborah Swing Sudhirkumar Yanpallewar Brad St Croix Jürgen Wess Oksana Gavrilova Lino Tessarollo |
author_sort |
Gianluca Fulgenzi |
title |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_short |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_full |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_fullStr |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_full_unstemmed |
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion |
title_sort |
novel metabolic role for bdnf in pancreatic β-cell insulin secretion |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-04-01 |
description |
Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release. |
url |
https://doi.org/10.1038/s41467-020-15833-5 |
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