Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.

Bibliographic Details
Main Authors: Gianluca Fulgenzi, Zhenyi Hong, Francesco Tomassoni-Ardori, Luiz F. Barella, Jodi Becker, Colleen Barrick, Deborah Swing, Sudhirkumar Yanpallewar, Brad St Croix, Jürgen Wess, Oksana Gavrilova, Lino Tessarollo
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15833-5
id doaj-b80c90e12332437a928a3eef0743440d
record_format Article
spelling doaj-b80c90e12332437a928a3eef0743440d2021-05-11T08:54:23ZengNature Publishing GroupNature Communications2041-17232020-04-0111111810.1038/s41467-020-15833-5Novel metabolic role for BDNF in pancreatic β-cell insulin secretionGianluca Fulgenzi0Zhenyi Hong1Francesco Tomassoni-Ardori2Luiz F. Barella3Jodi Becker4Colleen Barrick5Deborah Swing6Sudhirkumar Yanpallewar7Brad St Croix8Jürgen Wess9Oksana Gavrilova10Lino Tessarollo11Mouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMouse Cancer Genetics Program, CCR, NCI, NIHMolecular Signaling Section, Laboratory of Bioorganic Chemistry, NIDDK, NIHMouse Metabolism Core Laboratory, NIDDK, NIHMouse Cancer Genetics Program, CCR, NCI, NIHGlucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.https://doi.org/10.1038/s41467-020-15833-5
collection DOAJ
language English
format Article
sources DOAJ
author Gianluca Fulgenzi
Zhenyi Hong
Francesco Tomassoni-Ardori
Luiz F. Barella
Jodi Becker
Colleen Barrick
Deborah Swing
Sudhirkumar Yanpallewar
Brad St Croix
Jürgen Wess
Oksana Gavrilova
Lino Tessarollo
spellingShingle Gianluca Fulgenzi
Zhenyi Hong
Francesco Tomassoni-Ardori
Luiz F. Barella
Jodi Becker
Colleen Barrick
Deborah Swing
Sudhirkumar Yanpallewar
Brad St Croix
Jürgen Wess
Oksana Gavrilova
Lino Tessarollo
Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
Nature Communications
author_facet Gianluca Fulgenzi
Zhenyi Hong
Francesco Tomassoni-Ardori
Luiz F. Barella
Jodi Becker
Colleen Barrick
Deborah Swing
Sudhirkumar Yanpallewar
Brad St Croix
Jürgen Wess
Oksana Gavrilova
Lino Tessarollo
author_sort Gianluca Fulgenzi
title Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_short Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_full Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_fullStr Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_full_unstemmed Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
title_sort novel metabolic role for bdnf in pancreatic β-cell insulin secretion
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-04-01
description Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.
url https://doi.org/10.1038/s41467-020-15833-5
work_keys_str_mv AT gianlucafulgenzi novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT zhenyihong novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT francescotomassoniardori novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT luizfbarella novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT jodibecker novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT colleenbarrick novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT deborahswing novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT sudhirkumaryanpallewar novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT bradstcroix novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT jurgenwess novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT oksanagavrilova novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
AT linotessarollo novelmetabolicroleforbdnfinpancreaticbcellinsulinsecretion
_version_ 1721450349357694976

Similar Items