Characterization of a Phospho-Specific Antibody to the Fcε Receptor γ Chain, Reveals Differences in the Regulation of Syk and Akt Phosphorylation

Characterization of a Phospho-Specific Antibody to the Fcε Receptor γ Chain, Reveals Differences in the Regulation of Syk and Akt Phosphorylation

We previously demonstrated that the Fc receptor γ-chain Y58(C-terminal tyrosine) is highly susceptible to dephosphorylation; a mechanism that controls the extent of Syk activation and the downstream signaling in mast cells. Here, we explored the importance of the γ-chain Y47 (N-terminal tyrosine) in...

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Bibliographic Details
Main Authors: Juan Rivera, Barbara Dema, Sarah Leach, Ryo Suzuki
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Antibodies
Subjects:
phospho-specific antibody
mast cell
FcεRI
immunoreceptor tyrosine-based activation motif (ITAM)
Akt
Syk
Online Access:http://www.mdpi.com/2073-4468/2/2/321

Internet

http://www.mdpi.com/2073-4468/2/2/321

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