TLR4 Response to LPS Is Reinforced by Urokinase Receptor

GPI-anchored uPAR is the receptor for the extracellular serine protease urokinase-type plasminogen activator (uPA). Though uPAR role in inflammatory processes is documented, underlying mechanisms are not fully understood. In this study we demonstrate that uPAR is a part of Toll-like receptor 4 (TLR4...

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Bibliographic Details
Main Authors: Yulia Kiyan, Sergey Tkachuk, Song Rong, Anna Gorrasi, Pia Ragno, Inna Dumler, Hermann Haller, Nelli Shushakova
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.573550/full