Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization

Inflammatory activation of astroglia adds to the pathology of various neurological diseases. Astrocytes respond to microglia-derived cytokines such as interleukin-1α (IL-1α) with enhanced inflammatory signaling. This provokes pro-inflammatory gene expression of, among others, the e...

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Bibliographic Details
Main Authors: Alina Astakhova, Dmitry Chistyakov, Dominique Thomas, Gerd Geisslinger, Bernhard Brüne, Marina Sergeeva, Dmitry Namgaladze
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
astrocytes
inflammation
mitochondria
prostaglandins
Online Access:https://www.mdpi.com/2073-4409/8/10/1185

Internet

https://www.mdpi.com/2073-4409/8/10/1185

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