Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi.

Co-administration of a plasmid DNA encoding IL-15 improves long-term protection of a genetic vaccine against Trypanosoma cruzi.

Immunization of mice with the Trypanosoma cruzi trans-sialidase (TS) gene using plasmid DNA, adenoviral vector, and CpG-adjuvanted protein delivery has proven highly immunogenic and provides protection against acute lethal challenge. However, long-term protection induced by TS DNA vaccines has not b...

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Bibliographic Details
Main Authors: Christopher S Eickhoff, Jose R Vasconcelos, Nicole L Sullivan, Azra Blazevic, Oscar Bruna-Romero, Mauricio M Rodrigues, Daniel F Hoft
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3050911?pdf=render

Internet

http://europepmc.org/articles/PMC3050911?pdf=render

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