Facile supermolecular aptamer inhibitors of L-selectin.

Facile supermolecular aptamer inhibitors of L-selectin.

Multivalent interactions occur frequently in nature, where they mediate high-affinity interactions between cells, proteins, or molecules. Here, we report on a method to generate multivalent aptamers (Multi-Aptamers) that target L-selectin function using rolling circle amplification (RCA). We find th...

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Bibliographic Details
Main Authors: Elizabeth K Chang, Mark A Eckert, M Monsur Ali, Hamidreza Riazifar, Egest J Pone, Linan Liu, Weian Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4380364?pdf=render

Internet

http://europepmc.org/articles/PMC4380364?pdf=render

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