Biodegradable Gene Carriers Containing Rigid Aromatic Linkage with Enhanced DNA Binding and Cell Uptake

Biodegradable Gene Carriers Containing Rigid Aromatic Linkage with Enhanced DNA Binding and Cell Uptake

The linking and modification of low molecular weight cationic polymers (oligomers) has become an attracted strategy to construct non-viral gene carriers with good transfection efficiency and much reduced cytotoxicity. In this study, PEI 600 Da was linked by biodegradable bridges containing rigid aro...

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Bibliographic Details
Main Authors: Ju-Hui Zhang, Hui-Zhen Yang, Ji Zhang, Yan-Hong Liu, Xi He, Ya-Ping Xiao, Xiao-Qi Yu
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Polymers
Subjects:
non-viral vectors
gene delivery
polyethylenimine
structure–activity relationship
Online Access:http://www.mdpi.com/2073-4360/10/10/1080

Internet

http://www.mdpi.com/2073-4360/10/10/1080

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