Proximity assays for sensitive quantification of proteins

Proximity assays are immunohistochemical tools that utilise two or more DNA-tagged aptamers or antibodies binding in close proximity to the same protein or protein complex. Amplification by PCR or isothermal methods and hybridisation of a labelled probe to its DNA target generates a signal that enab...

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Bibliographic Details
Main Authors: Christina Greenwood, David Ruff, Sara Kirvell, Gemma Johnson, Harvinder S. Dhillon, Stephen A. Bustin
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Biomolecular Detection and Quantification
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214753515000273