Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists

Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists

5-Hydroxytryptamine type 2A (5-HT2A) receptor is an important target for developing innovative antipsychotic agents in neuropsychiatric disorder therapies. To search for 5-HT2A receptor antagonists, a new indole alkaloid termed 6-bromo-N-propionyltryptamine (1), together with one known homologue 6-b...

Full description

Bibliographic Details
Main Authors: Lijian Ding, Shan He, Wei Wu, Haixiao Jin, Peng Zhu, Jinrong Zhang, Tingting Wang, Ye Yuan, Xiaojun Yan
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Molecules
Subjects:
6-bromotryptamine
Pseudoalteromonas rubra
5-HT2A receptor
antagonist
Online Access:http://www.mdpi.com/1420-3049/20/9/17675

Internet

http://www.mdpi.com/1420-3049/20/9/17675

Similar Items