A New Human Leukocyte Antigen Typing Algorithm Combined With Currently Available Genotyping Tools Based on Next-Generation Sequencing Data and Guidelines to Select the Most Likely Human Leukocyte Antigen Genotype

A New Human Leukocyte Antigen Typing Algorithm Combined With Currently Available Genotyping Tools Based on Next-Generation Sequencing Data and Guidelines to Select the Most Likely Human Leukocyte Antigen Genotype

BackgroundHigh-precision human leukocyte antigen (HLA) genotyping is crucial for anti-cancer immunotherapy, but existing tools predicting HLA genotypes using next-generation sequencing (NGS) data are insufficiently accurate.Materials and MethodsWe compared availability, accuracy, correction score, a...

Full description

Bibliographic Details
Main Authors: Miseon Lee, Jeong-Han Seo, Sungjae Song, In Hye Song, Su Yeon Kim, Young-Ae Kim, Gyungyub Gong, Jeong Eun Kim, Hee Jin Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
human leukocyte antigen (HLA)
HLA genotype
next-generation sequencing data (NGS)
HLA typing algorithm
immunotherapy
neoantigen
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.688183/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.688183/full

Similar Items