SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.

SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53.

<h4>Background</h4>The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53...

Full description

Bibliographic Details
Main Authors: Cian J Lynch, Zahid H Shah, Simon J Allison, Shafiq U Ahmed, Jack Ford, Lorna J Warnock, Han Li, Manuel Serrano, Jo Milner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20975832/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20975832/?tool=EBI

Similar Items