Activated factor X targeted stored in platelets as an effective gene therapy strategy for both hemophilia A and B

Activated factor X targeted stored in platelets as an effective gene therapy strategy for both hemophilia A and B

Abstract Background Treatment of hemophiliacs with inhibitors remains challenging, and new treatments are in urgent need. Coagulation factor X plays a critical role in the downstream of blood coagulation cascade, which could serve as a bypassing agent for hemophilia therapy. Base on platelet‐targete...

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Bibliographic Details
Main Authors: Dawei Wang, Xiaohu Shao, Qiang Wang, Xiaohong Pan, Yujun Dai, Shuxian Yao, Tong Yin, Zhugang Wang, Jiang Zhu, Xiaodong Xi, Zhu Chen, Saijuan Chen, Guowei Zhang
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Clinical and Translational Medicine
Subjects:
factor X
gene therapy
hemophilia
inhibitor
platelet
Online Access:https://doi.org/10.1002/ctm2.375

Internet

https://doi.org/10.1002/ctm2.375

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