CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline

CHOP Regulates Endoplasmic Reticulum Stress-Mediated Hepatoxicity Induced by Monocrotaline

Monocrotaline (MCT), a pyrrolizidine alkaloid, is the major toxin in Crotalaria, which causes cell apoptosis in humans and animals. It has been reported that the liver is a vulnerable target of MCT. However, the exact molecular mechanism of the interaction between endoplasmic reticulum (ER) stress a...

Full description

Bibliographic Details
Main Authors: Yazhou Guo, Chen Yang, Rong Guo, Ruijie Huang, Yongxia Su, Shuai Wang, Yezi Kong, Jianguo Wang, Chengjian Tan, Chonghui Mo, Chenchen Wu, Baoyu Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
monocrotaline
hepatotoxicity
endoplasmic reticulum stress
CHOP
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.685895/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.685895/full

Similar Items