Structural and functional insights into the HIV-1 maturation inhibitor binding pocket.

Structural and functional insights into the HIV-1 maturation inhibitor binding pocket.

Processing of the Gag precursor protein by the viral protease during particle release triggers virion maturation, an essential step in the virus replication cycle. The first-in-class HIV-1 maturation inhibitor dimethylsuccinyl betulinic acid [PA-457 or bevirimat (BVM)] blocks HIV-1 maturation by inh...

Full description

Bibliographic Details
Main Authors: Kayoko Waki, Stewart R Durell, Ferri Soheilian, Kunio Nagashima, Scott L Butler, Eric O Freed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3493477?pdf=render

Internet

http://europepmc.org/articles/PMC3493477?pdf=render

Similar Items