iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity

iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity

Developing lymphocytes express the recombination activating genes (RAGs) 1 and 2 products that form a site specific recombinase complex (RAG), introducing double strand DNA breaks (DSBs) at recombination signal sequences (RSSs) flanking the V, D, and J gene segments in the antigen receptor loci. The...

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Bibliographic Details
Main Authors: Marie Bonnet, Leonor Morais Sarmento, Ana C. Martins, Daniel Sobral, Joana Silva, Jocelyne Demengeot
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
recombination activating gene
transgenic mouse model
4-hydroxytamoxifen induction
estrogen receptor
lymphocyte development
V(D)J recombination
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01525/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01525/full

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