MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

Background: Acute myeloid leukemia (AML) is a group of heterogeneous hematologic malignancies correlates with poor prognosis. It is important to identify biomarkers for effective treatment of AML. Kinases participate in many regulatory pathways and biological activities in AML. Previous studies demo...

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Bibliographic Details
Main Authors: Qing Ling, Fenglin Li, Xiang Zhang, Shihui Mao, Xiangjie Lin, Jiajia Pan, Wenle Ye, Wenwen Wei, Yu Qian, Chao Hu, Xin Huang, Jinghan Wang, Huafeng Wang, Jiansong Huang, Yungui Wang, Jie Jin
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:EBioMedicine
Subjects:
Acute myeloid leukemia
MAP4K1
Homoharringtonine resistance
Prognosis
DNA damage
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421002346

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http://www.sciencedirect.com/science/article/pii/S2352396421002346

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