Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities

Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities

Summary: Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in HUWE1 cause heterogenous neurodevelopmental X-linked intellectual disabilities (XLIDs), the disease mechanisms common to these syndromes remain unknown. In...

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Bibliographic Details
Main Authors: Rossana Aprigliano, Merdane Ezgi Aksu, Stefano Bradamante, Boris Mihaljevic, Wei Wang, Kristin Rian, Nicola P. Montaldo, Kayla Mae Grooms, Sarah L. Fordyce Martin, Diana L. Bordin, Matthias Bosshard, Yunhui Peng, Emil Alexov, Cindy Skinner, Nina-Beate Liabakk, Gareth J. Sullivan, Magnar Bjørås, Charles E. Schwartz, Barbara van Loon
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports Medicine
Subjects:
X-linked intellectual disability
E3 ubiquitin ligase
HUWE1
p53
neurodevelopment
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121000562

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http://www.sciencedirect.com/science/article/pii/S2666379121000562

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