Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug

Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug

The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent. The phase-solubility method was applied to determine drug solubility in binary and ternary systems. The results showed th...

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Bibliographic Details
Main Authors: Suporn Charumanee, Siriporn Okonogi, Jakkapan Sirithunyalug, Peter Wolschann, Helmut Viernstein
Format: Article
Language:English
Published: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2016-10-01
Series:Scientia Pharmaceutica
Subjects:
cyclodextrins
co-solvent
co-solubilization
inclusion complexation
piroxicam
Online Access:http://www.mdpi.com/2218-0532/84/4/694

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http://www.mdpi.com/2218-0532/84/4/694

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