Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug
The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent. The phase-solubility method was applied to determine drug solubility in binary and ternary systems. The results showed th...
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Österreichische Apotheker-Verlagsgesellschaft m. b. H.
2016-10-01
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doaj-b856a0cd91de476f896477633035fb9d2020-11-25T02:27:31ZengÖsterreichische Apotheker-Verlagsgesellschaft m. b. H.Scientia Pharmaceutica2218-05322016-10-0184469470410.3390/scipharm84040694scipharm84040694Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble DrugSuporn Charumanee0Siriporn Okonogi1Jakkapan Sirithunyalug2Peter Wolschann3Helmut Viernstein4Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mail 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mail 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mail 50200, ThailandDepartment of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, Vienna 1090, AustriaDepartment of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, Vienna 1090, AustriaThe aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent. The phase-solubility method was applied to determine drug solubility in binary and ternary systems. The results showed that in systems consisting of the drug dissolved in ethanol–water mixtures, the drug solubility increased exponentially with a rising concentration of ethanol. The phase solubility measurements of the drug in aqueous solutions of CDs, β-CD and γ-CD exhibited diagrams of AL-type, whereas 2,6-dimethyl-β-CD revealed AP-type. The destabilizing effect of ethanol as a co-solvent was observed for all complexes regardless of the CD type, as a consequence of it the lowering of the complex formation constants. In systems with a higher concentration of ethanol, the drug solubility was increased in opposition to the decreasing complex formation constants. According to this study, the type of CDs played a more important role on the solubility of Prx, and the use of ethanol as a co-solvent exhibited no synergistic effect on the improvement of Prx solubility. The Prx solubility was increased again due to the better solubility in ethanol.http://www.mdpi.com/2218-0532/84/4/694cyclodextrinsco-solventco-solubilizationinclusion complexationpiroxicam |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suporn Charumanee Siriporn Okonogi Jakkapan Sirithunyalug Peter Wolschann Helmut Viernstein |
spellingShingle |
Suporn Charumanee Siriporn Okonogi Jakkapan Sirithunyalug Peter Wolschann Helmut Viernstein Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug Scientia Pharmaceutica cyclodextrins co-solvent co-solubilization inclusion complexation piroxicam |
author_facet |
Suporn Charumanee Siriporn Okonogi Jakkapan Sirithunyalug Peter Wolschann Helmut Viernstein |
author_sort |
Suporn Charumanee |
title |
Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug |
title_short |
Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug |
title_full |
Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug |
title_fullStr |
Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug |
title_full_unstemmed |
Effect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug |
title_sort |
effect of cyclodextrin types and co-solvent on solubility of a poorly water soluble drug |
publisher |
Österreichische Apotheker-Verlagsgesellschaft m. b. H. |
series |
Scientia Pharmaceutica |
issn |
2218-0532 |
publishDate |
2016-10-01 |
description |
The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent. The phase-solubility method was applied to determine drug solubility in binary and ternary systems. The results showed that in systems consisting of the drug dissolved in ethanol–water mixtures, the drug solubility increased exponentially with a rising concentration of ethanol. The phase solubility measurements of the drug in aqueous solutions of CDs, β-CD and γ-CD exhibited diagrams of AL-type, whereas 2,6-dimethyl-β-CD revealed AP-type. The destabilizing effect of ethanol as a co-solvent was observed for all complexes regardless of the CD type, as a consequence of it the lowering of the complex formation constants. In systems with a higher concentration of ethanol, the drug solubility was increased in opposition to the decreasing complex formation constants. According to this study, the type of CDs played a more important role on the solubility of Prx, and the use of ethanol as a co-solvent exhibited no synergistic effect on the improvement of Prx solubility. The Prx solubility was increased again due to the better solubility in ethanol. |
topic |
cyclodextrins co-solvent co-solubilization inclusion complexation piroxicam |
url |
http://www.mdpi.com/2218-0532/84/4/694 |
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