Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model

Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX–Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model

Background/Aims: The effect of impaired intracellular proline availability for proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis was studied. Methods: We generated a constitutively knocked-down PRODH/POX MCF-7 breast cancer cell line (MCF-7shPRODH/POX) as a model to analyze the f...

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Bibliographic Details
Main Authors: Ilona Zareba, Arkadiusz Surazynski, Marcin Chrusciel, Wojciech Miltyk, Milena Doroszko, Nafis Rahman, Jerzy Palka
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Apoptosis
Collagen biosynthesis
MCF-7 breast cancer cells
Proline
Proline dehydrogenase/proline oxidase
Online Access:http://www.karger.com/Article/FullText/480653

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http://www.karger.com/Article/FullText/480653

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