An Investigation into the Potential of Targeting <i>Escherichia coli rne</i> mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy

An Investigation into the Potential of Targeting <i>Escherichia coli rne</i> mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy

The increase in antibacterial resistance is a serious challenge for both the health and defence sectors and there is a need for both novel antibacterial targets and antibacterial strategies. RNA degradation and ribonucleases, such as the essential endoribonuclease RNase E, encoded by the <i>rn...

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Bibliographic Details
Main Authors: Layla R. Goddard, Charlotte E. Mardle, Hassan Gneid, Ciara G. Ball, Darren M. Gowers, Helen S. Atkins, Louise E. Butt, Jonathan K. Watts, Helen A. Vincent, Anastasia J. Callaghan
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
antibacterial
antisense oligonucleotide
gapmer
locked nucleic acid (LNA)
RNase E
RNase H
Online Access:https://www.mdpi.com/1420-3049/26/11/3414

Internet

https://www.mdpi.com/1420-3049/26/11/3414

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